In a recent study published in Nature Communications, researchers investigated whether USP30 inhibition can serve as a disease-modifying therapy for Parkinson's disease (PD) by enhancing mitophagy and reducing α-synuclein (αSyn) pathology. The study found that knockout or inhibition of USP30 protected dopaminergic neurons in a Parkinson's disease mouse model.
Mitochondrial dysfunction and αSyn toxicity are key factors in PD, and targeting USP30 could potentially break the cycle of dysfunction and αSyn accumulation
Source: Healthcare Press (healthcarepress.net)
USP30 Parkinson's Disease Mitophagy Α-Synuclein Therapy
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