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Modular Nanoparticles for Tailored Applications

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Modular Nanoparticles,Targeted Drug Delivery,Biological Agents

Researchers have developed a new technology that allows for the customization of nanoparticles for various applications, such as drug delivery and neutralizing biological agents. By using a modular nanoparticle base, proteins can be easily attached to target specific biological entities, eliminating the need for creating distinct nanoparticles for each target. This plug and play platform technology enables rapid modification of functional biological nanoparticles.

Reviewed by Danielle Ellis, B.Sc.Oct 30 2023 The surface of the nanoparticles is engineered to host any biological molecules of choice, making it possible to tailor the nanoparticles for a wide array of applications, ranging from targeted drug delivery to neutralizing biological agents .

The modular nanoparticles consist of biodegradable polymer cores coated with genetically modified cell membranes. The key to their modular design is a pair of synthetic proteins, known as SpyCatcher and SpyTag, that are specifically designed to spontaneously-;and exclusively-;bind with each other. This pair is commonly used in biological research to combine various proteins.

Related StoriesTo create the modular nanoparticles, the researchers first genetically engineered human embryonic kidney 293 cells-;a commonly used cell line in biological research-;to express SpyCatcher proteins on their surface. The cell membranes were then isolated, broken into smaller pieces, and coated onto biodegradable polymer nanoparticles.

Source: Tech Daily Report (techdailyreport.net)

Modular Nanoparticles Targeted Drug Delivery Biological Agents Customization Plug And Play Technology

 

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