Cryo-EM structures of amyloid-β 42 filaments from human brains

We thank the patients’ families for donating brain tissues; U. Kuederli, M. Jacobsen, F. Epperson, and R. M. Richardson for human brain collection and technical support; T. Saido for providingmice; T. Darling and J. Grimmett for help with high-performance computing; G. Singla Lezcano for help with Falcon 4i; and Y. Shi, J. Collinge, and C. Haass for helpful discussions. This study was supported by the Electron Microscopy Facility of the MRC Laboratory of Molecular Biology. M.G.

Maps have been deposited in the Electron Microscopy Data Bank with the accession codes EMDB 13800 and 13809. Atomic coordinates have been deposited in the Protein Data Bank under accession codes 7Q4B and 7Q4M. Please address requests for materials to the corresponding authors.

I do not understand if the high symmetry in these pictures is relevant for the physiology or just a technical artefact

I hope they understand everything soon.

Amyloid diseases = CNS diseases like Parkinson’s, Alzheimer’s etc. the most dreaded, the ones with no known/reliable treatment. Does understanding the development of them mean meaning able to nip them off on the bud or will it be just another study, time will tell.

MichelGoed Good evening sir, how are you? Nice to meet you, I'm Louise and I'm in the trade field. I'd like to correspond with you if you don't mind, here is my address berthierlouise305gmail.com You can leave me an invitation on Hangouts so that we can get to know each other better.

- Charles Darwin: 'I am quite conscious that my speculations run quite beyond the bounds of true science.' (from a letter to Asa Gray, Harvard biology professor, cited in 'Charles Darwin and the Problem of Creation,' N.C. Gillespie, p.2

Amazing.....

Ok

Si, por eso......tienes que conocerlos y comprenderlos para no desarrollar una enfermedad cerebral

demoyokatta Fascinating.....

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