The Power of Psychobiotics in Depression: A Modern Approach through the Microbiota–Gut–Brain Axis

By Pooja Toshniwal PahariaApr 8 2024Reviewed by Susha Cheriyedath, M.Sc. In a recent review published in the journal Nutrients, researchers investigated the psychobiotic treatment of depression by restoring microbial balance and regulating the microbiome-gut-brain axis .

The Power of Psychobiotics in Depression: A Modern Approach through the Microbiota–Gut–Brain Axis: A literature Review. Image Credit: T. L. Furrer / Shutterstock Association between the gut-brain axis and depressive disorders Depression is a complex biological disorder influenced by a variety of molecular mechanisms, such as neurotransmitter reduction, a decrease in brain-derived neurotrophic factor , an abnormally stressed HPA axis, an increase in pro-inflammatory gut microbial responses, and vagus nerve interaction between gut microbiota and brain.

Impact of probiotic gut microbes on depression Psychobiotics are probiotic bacteria that boost mental health by improving the intestinal barrier and modifying the immune response in the gut-associated lymphoid tissue , which plays a role in inflammation development. The gut microbiota is crucial in the pathophysiology of depression since it regulates inflammatory processes. Bifidobacterium breve boosts BDNF levels, lowers interleukin-6 and TNF-alpha levels, and enhances cognitive function.

Psychobiotics Depression Microbial Balance Microbiome-Gut-Brain Axis Dysbiosis Gut-Brain Axis Supportive Treatment Treatment-Recalcitrant Depression

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