MicroRNAs May Predict Pancreatic Cancer Risk Years Before Diagnosis

Early detection of pancreatic cancer could improve patient prognosis, but clinically viable biomarkers are lacking. In a two-stage study, researchers screened and validated circulating miRNAsas biomarkers for early detection using prediagnostic plasma samples from 462 case-control pairs across multiple cohorts.

The discovery stage included 185 pairs from the PLCO Cancer Screening Trial, and the replication stage included 277 pairs from Shanghai Women's/Men's Health Study, Southern Community Cohort Study, and Multiethnic Cohort Study. Overall, 798 plasma microRNAs were measured using the NanoString nCounter Analysis System, and odds ratios for pancreatic cancer risk were calculated on the basis of miRNA concentrations.In the discovery stage, the researchers identified 120 miRNAs significantly associated with pancreatic cancer risk.

Three of these miRNAs showed consistent significant associations in the replication stage. Specifically, hsa-miR-199a-3p/hsa-miR-199b-3p and hsa-miR-191-5p were associated with a 10%-11% lower risk for pancreatic cancer , and hsa-miR-767-5p was associated with an 8% higher risk for pancreatic cancer within 5 years of the blood draw.

In age-stratified analyses, hsa-miR-767-5p along with four other miRNAs — hsa-miR-640 , hsa-miR-874-5p , hsa-miR-1299 , and hsa-miR-449b-5p — were associated with an increased risk for pancreatic cancer among patients diagnosed at age 65 or older.

Source: Healthcare Press (healthcarepress.net)

Pancreatic Cancer Cancer Of The Pancreas Genomics Genomic Medicine Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Cancer Risk Mirna Microrna Leukemia Leukaemia Blood Cancer Plasma Biomarker Biological Marker Multi-Biomarker Disease Activity MBDA Multibiomarker Disease Activity Blood

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