Magnesium and Metabolic Syndrome: Any Connection?

Higher urinary magnesium loss, as indicated by an elevated magnesium depletion score , may be an independent risk factor forResearchers examined the relationship between magnesium status and metabolic syndrome in 15,565 US adults participating in the National Health and Nutrition Examination Survey , of whom 5438 had metabolic syndrome .

Magnesium deficiency was predicted by MDS, a four-factor score that aggregates diuretic use , proton pump inhibitor , kidney function , and heavy MDS was categorized into six levels , with a higher MDS indicating a more severe magnesium deficiency.Even after adjusting for potential confounding factors, each 1-unit increase in the MDS increased the odds of metabolic syndrome by about 30% .

A dose-response relationship was observed between MDS and metabolic syndrome, with MDS level 1 being associated with 1.28-fold higher odds of metabolic syndrome than MDS level 0; further escalation in the odds was noted for MDS levels 2, 3, and 4. The association between metabolic syndrome and MDS remained consistent across all population subgroups defined by age, gender, race , body mass index, drinking status, or smoking status."It is possible to prevent and reduce MetS by supplementing with magnesium supplements or encouraging higher magnesium intake diet because the diet is a factor that can be changed," the authors wrote.

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