A diet high in fat and sugar , for even a limited period before conception, could compromise maternal metabolic physiology, impair lactation, and potentially harm neonatal outcomes, according to scientists from the Centre for Trophoblast Research at the University of Cambridge.
Co-lead author Amanda Sferruzzi-Perri, professor in fetal and placental physiology at the University of Cambridge, said: "We wanted to know what was going on, because the mothers looked okay, they weren't large in terms of their size. But what we found was that although the mice seemed to have okay rates of getting pregnant, they did have greater amounts of adipose – fat tissue – in their body in and at the start of pregnancy.
The clinical relevance of their study is that "when a woman of larger size is pregnant, clinicians are often most concerned about the risk of diabetes and abnormal baby growth. But in mums-to-be who look healthy, regardless of their food intake, subtle, but potentially dangerous changes in pregnancy may slip under the radar", the authors commented.
"They might have greater adiposity – higher levels of fat mass – which we know is a predictor of many health problems. That may not overtly impact on their ability to become pregnant but could have consequences for the growth of the baby before birth, and the health and wellbeing of the baby after birth."
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