Ultraprocessed foods , ready-to-eat-or-heat industrial formulations made with ingredients extracted from foods or synthesized in laboratories, have gradually been replacing traditional foods and meals made from fresh and minimally processed ingredients in many countries.
Across all age groups and sex strata, consumption of UPFs ranged from 13% to 21% of total food intake in Brazil during the period studied. A total of 541,260 adults aged 30 to 69 died prematurely in 2019, of whom 261,061 were from preventable,. The model found that approximately 57,000 deaths that year could be attributed to the consumption of UPFs, which corresponded to 10.5% of all premature deaths and 21.8% of all deaths from preventable noncommunicable diseases in adults aged 30 to 69.
physorg_com Bud but… fake meat is supposed to save us
physorg_com Anti matter energi
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Drugging KRAS: current perspectives and state-of-art review - Journal of Hematology & OncologyAfter decades of efforts, we have recently made progress into targeting KRAS mutations in several malignancies. Known as the ‘holy grail’ of targeted cancer therapies, KRAS is the most frequently mutated oncogene in human malignancies. Under normal conditions, KRAS shuttles between the GDP-bound ‘off’ state and the GTP-bound ‘on’ state. Mutant KRAS is constitutively activated and leads to persistent downstream signaling and oncogenesis. In 2013, improved understanding of KRAS biology and newer drug designing technologies led to the crucial discovery of a cysteine drug-binding pocket in GDP-bound mutant KRAS G12C protein. Covalent inhibitors that block mutant KRAS G12C were successfully developed and sotorasib was the first KRAS G12C inhibitor to be approved, with several more in the pipeline. Simultaneously, effects of KRAS mutations on tumour microenvironment were also discovered, partly owing to the universal use of immune checkpoint inhibitors. In this review, we discuss the discovery, biology, and function of KRAS in human malignancies. We also discuss the relationship between KRAS mutations and the tumour microenvironment, and therapeutic strategies to target KRAS. Finally, we review the current clinical evidence and ongoing clinical trials of novel agents targeting KRAS and shine light on resistance pathways known so far.
Source: BioMedCentral - 🏆 22. / 71 Read more »
American society is so focused on race that it is blind to classThe end of affirmative action in college admissions could be a chance to build a better system Queremos que as instituições brasileiras respeitem a constituição, queremos o fim da juristocracia no Brasil, nós brasileiros queremos de volta nossa liberdade de expressão e o fim da censura prévia! Digo não ao comunismo! Digo não a volta da corrupção ao Brasil! Affirmative action is a racist initiative purely based on race, which is unfair to poor black, Hispanic, Asian kids. It benefits rich kids who have more resources. College admission should in part consider income level instead of race Yes only the rich can go
Source: TheEconomist - 🏆 6. / 92 Read more »
Who wins from the unravelling of Sino-American trade?From disease to deteriorating Chinese-American relations, there have been successive blows to the world’s trading system. The latest threat stems from the possibility of another global recession Nobody wins from the trade war started by the US. Good India
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Cannabis, cocaine, methamphetamine, and opiates increase risk of atrial fibrillationCannabis, cocaine, methamphetamine, and opiates increase risk of atrial fibrillation AtrialFibrillation Cannabis Cocaine Methamphetamine Opiates Cardiology ehj_ed UCSF
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Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk | NEJMOriginal Article from The New England Journal of Medicine — Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk BrighamWomens NEJM cholesterol cardiovascular triglycerides lipids lipidmetabolism NAFLD hepatology heartdisease hearthealth Bisphenol A (BPA) induces triglyceride accumulation in the liver . . Melatonin reduces triglyceride levels. .
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'Let me take you on a tour on the Old Farm Bus'A man has transformed his family farm into a community space - with the help of an American school bus. American urban street culture for people who hate the countryside so much that they want to make it like somewhere else. Give me strength. 🤦♂️
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