Salk scientists explain how CBN protects the brain against aging and neurodegeneration

Apr 17 2024Salk Institute One in every 10 individuals above the age of 65 develops an age-related neurological disorder like Alzheimer's or Parkinson's, yet treatment options remain sparse for this population. Scientists have begun exploring whether cannabinoids-;compounds derived from the cannabis plant, like well-known THC and CBD -;may offer a solution.

Not only does CBN have neuroprotective properties, but its derivatives have the potential to become novel therapeutics for various neurological disorders. We were able to pinpoint the active groups in CBN that are doing that neuroprotection, then improve them to create derivative compounds that have greater neuroprotective ability and drug-like efficacy.

"We were looking for CBN analogs that could get into the brain more efficiently, act more quickly, and produce a stronger neuroprotective effect than CBN itself," says Zhibin Liang, first author and postdoctoral researcher in Maher's lab. "The four CBN analogs we landed on had improved medicinal chemical properties, which was exciting and really important to our goal of using them as therapeutics.

"Our findings help demonstrate the therapeutic potential of CBN, as well as the scientific opportunity we have to replicate and refine its drug-like properties," says Maher. "Could we one day give this CBN analog to football players the day before a big game, or to car accident survivors as they arrive in the hospital? We're excited to see how effective these compounds might be in protecting the brain from further damage.

Aging Cannabidiol Cannabinoid Cannabis Cell Drug Discovery Ferroptosis Fruit Mitochondria Molecule Neurodegeneration Neurons Research Tetrahydrocannabinol Therapeutics Traumatic Brain Injury

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