Apr 17 2024Dana-Farber Cancer Institute
The KEYNOTE-564 trial was designed to evaluate adjuvant pembrolizumab following nephrectomy within 12 weeks prior to randomization. The double-blind, phase 3 study, carried out at hundreds of sites internationally, enrolled 994 patients who were randomized to pembrolizumab once every three weeks for about a year, or a placebo. Pembrolizumab targets a molecular pathway that cancer cells commandeer to evade attack by the body's immune system.
Related Stories"Since 1973, more than 12,000 patients with kidney cancer participated in adjuvant studies versus a control arm and none of the studies showed the experimental arm extends lives until now with the KEYNOTE-564 study," says Choueiri. "We showed pembrolizumab extends survival. It doesn't only delay recurrence."
Immunotherapy Kidney Kidney Cancer Surgery Adjuvant Therapy Carcinoma Cell Children Hospital Immune System Medicine Nephrectomy Oncology Placebo Research
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