Researchers study how cells adapt to stressful and complex environments

Reviewed by Lily Ramsey, LLMOct 16 2023 But then the sun shines through a window, the section of the counter where the bowl is sitting heats up, and suddenly life gets uncomfortable for the humble yeast. When temperatures get too high, the cells shut down their normal processes to ride out the stressful conditions and live to feast on grapes on another, cooler day.

Ali works in the lab of David Pincus, PhD, Assistant Professor of Molecular Genetics and Cell Biology at UChicago, where their team studies study how cells adapt to stressful and complex environments, including the heat shock response.

Loosely affiliated biomolecular goo Ribosomes are crucial machines inside the cytoplasm of all cells that read the genetic instructions on messenger RNA and build chains of amino acids that fold into proteins. Producing ribosomes to perform this process is energy intensive, so under conditions of stress like heat shock, it's one of the first things a cell shuts down to conserve energy.

Related StoriesUsing these combined imaging tools, the researchers saw that the orphaned proteins were collected into liquid-like droplets of material near the nucleolus . These blobs were accompanied by molecular chaperones, proteins that usually assist the ribosomal production process by helping fold new proteins. In this case, the chaperones seemed to be "stirring" the collected proteins, keeping them in a liquid state and preventing them from clumping together.

Finding structure at an atomic scale In the future, Ali hopes to employ another imaging technique called cryo-electron tomography, an application using an electron microscope while cell samples are frozen to capture images of their interior components at an atomic level of resolution. Another advantage of this technique is that it allows researchers to capture 3D images inside the cell itself, as opposed to separating and preparing proteins for imaging.

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