Reviewed by Danielle Ellis, B.Sc.Oct 16 2023 But targeted therapies can often inhibit other unknown proteins. These hidden targets may also contribute to the drug's anticancer effects and potentially offer a path for the drug to be repurposed for other cancers controlled by the hidden target.
Drugs with polypharmacology mechanisms, meaning agents that target multiple functionally relevant proteins, may have the potential to effectively overcome drug resistance, improve anti-cancer activity of single-targeted inhibitors and produce a more durable patient response and remission." Rix and a team of Moffitt researchers wanted to determine whether cancer drugs that target the protein ROS1 in non-small cell lung cancer have additional hidden targets.
Related StoriesThe team performed additional laboratory experiments and found that lorlatinib also targets the protein PYK2. This protein plays an important role in focal adhesions, which are cell structures that are involved in several processes including cell adhesion, movement and survival. Their studies also showed that the protein SRC physically associated with PYK2 and ROS1 and helped control the activity of PYK2.
Source: Healthcare Press (healthcarepress.net)
We have summarized this news so that you can read it quickly. If you are interested in the news, you can read the full text here. Read more:
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Survey finds education is needed to identify lesser-known symptoms of breast cancerAn overwhelming majority of adults (93%) recognize a lump as a symptom of breast cancer, but less than half recognize other common symptoms associated with the disease, according to a consumer survey commissioned by The Ohio State University Comprehensive Cancer Center—Arthur G. James Cancer Hospital and Richard J.
Source: medical_xpress - 🏆 101. / 51 Read more »
Black men more likely to get prostate cancer - we need to discuss it‘I would like to reiterate the message to Black men that there is no shame in having any kind of illness.'
Source: MetroUK - 🏆 13. / 82 Read more »
'Breast cancer was my calling - I’ve posed topless and trekked with Pete WicksEXCLUSIVE: Mum of two Danni Moore found a lump as she breastfed her baby but despite undergoing a double mastectomy the beauty therapist from Bristol is determined to inspire others
Source: new_magazine - 🏆 72. / 59 Read more »
Elena Kostyuchenko: The ‘poisoned’ Russian journalist facing lifelong cancer tests after challenging PutinAfter exposing Ukrainian torture claims and Russian 'concentration camps', reporter Elena Kostyuchenko believes she was poisoned by Moscow agents. One year on, she reveals her ongoing health problems
Source: i newspaper - 🏆 8. / 89 Read more »
Woman 'looked seven months pregnant' after shock ovarian cancer diagnosisPauline Donnelly was diagnosed Stage 4 ovarian cancer that had spread to her chest, oesophagus, heart and bowel.
Source: Daily_Record - 🏆 9. / 89 Read more »
NI woman on how she 'looked seven months pregnant' after cancer diagnosis'Not only did I have ovarian cancer but, because it had spread outside of the abdomen into my chest, around my oesophagus and heart and on my bowel, it was stage 4b'
Source: BelfastLive - 🏆 16. / 77 Read more »