An experimental HIV vaccine first tested in Thailand has triggered a surprisingly strong immune response in South African volunteers, though the region is home to a different strain of the virus, research published this week in the international peer review journal, Science Translational Medicine, shows.
The study results challenge the idea that each region of the world needs its own type of vaccine, tailored to the local strains of HIV, said Glenda Gray, the study’s principal investigator and president of the Medical Research Council. Preliminary analysis of the results, presented at a conference in Cape Town in 2014, found South Africans mounted an equally good immune response as Thais. Now, a closer look, with new and better tools, has revealed that the vaccine in fact elicited a stronger immune response at the cellular and antibody levels in the South African volunteers.
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