One of the fundamental goals of basic biology is understanding how diverse cell types work in concert to form tissues, organs, and organ systems. Recent efforts to catalog the different cell types in every tissue in our bodies are a step in the right direction, but only one piece of the puzzle. The great mystery of how those cells communicate with one another remains unsolved.
Originally, the platform had narrow applications. Victora and colleagues designed LIPSTIC to record a very specific kind of cell-to-cell interaction between T cells and B cells, a major focus of their lab. Other researchers, however, began clamoring for a version of LIPSTIC that would work on other cellular interactions too."We could have tailored a LIPSTIC for every type of interaction," Victora says.
"The reception to uLIPSTIC has been great," says Sandra Nakandakari-Higa, a PhD student in the Victora lab and lead author on the paper."We're already getting a lot of inquiries from other labs about how they can adapt our system to their models."
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