A twice-daily dose of a proton pump inhibitor ( PPI ) leads to higher histologic response rates in patients with eosinophilic esophagitis (EoE), according to a retrospective cohort study. The study aimed to determine the optimal dosing strategy for inducing histologic remission in patients with EoE. The researchers recruited 305 adult patients with newly diagnosed, treatment-naive EoE and compared the efficacy of standard, moderate, and high PPI doses.
The primary outcome was a histologic response, defined as fewer than 15 eosinophils/hpf on repeat esophageal biopsies. The study found that the twice-daily 20 mg PPI dose had a higher histologic response rate compared to the once-daily 40 mg PPI dose in the moderate-dose group
PPI Proton Pump Inhibitor Histologic Response Eosinophilic Esophagitis Eoe Dosing Strategy
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