The role of NSP6 in the biogenesis of the SARS-CoV-2 replication organelle - Nature

SARS-CoV-2, like other coronaviruses, builds a membrane-bound replication organelle to enable RNA replication. The SARS-CoV-2 RO is composed of double membrane vesicles tethered to the endoplasmic reticulum by thin membrane connectors, but the viral proteins and the host factors involved are currently unknown. Here we identify the viral non-structural proteins that generate the SARS-CoV-2 RO.

Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz , Fundação Oswaldo Cruz , Rio de Janeiro, RJ, BrazilPrograma de Imunologia e Inflamação, Universidade Federal do Rio de Janeiro, UFRJ, Rio de Janeiro, Rio de Janeiro, BrazilCentro de Desenvolvimento Tecnológico em Saúde and National Institute for Science and Technology on Innovation on Diseases of Neglected Populations , FIOCRUZ, Rio de Janeiro, BrazilGiovanna Fusco, Maurizio Viscardi & Sergio...

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