Pig-heart transplant pioneer on how breakthrough surgery became possible

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Pakistani-American scientist behind the first pig-to-human heart transplant breakthrough hopes to save many more lives

In the early 1990s when Dr. Muhammad Mansoor Mohiuddin was practicing to become a heart transplant surgeon he received a word of advise that changed the way he wanted to help his patients.

There are never enough human donors around to save thousands of patients on the waiting list. In the US alone, more than 110,000 people are waiting for donor organs including kidneys and heart. His efforts finally paid off in January 7 when his team at the University of Maryland School of Medicine successfully transplanted a heart of a genetically modified pig into a man suffering from a severe heart ailment.

It’s due to the strong immune response. Even in normal human-to-human organ transplants, doctors use strong immunosuppressant drugs to reduce the rejection rate. The combination of gene-editing tools, KPL-404, and the special solution made by a Swedish company to help preserve the pig’s heart made Bennett’s successful transplant possible, says Mohiuddin. Even though a heart from a genetically modified pig has been successfully attached to a baboon’s body with the help of the drug Mohiuddin developed, it wasn’t tested on a human before.

The transplant process still has to undergo clinical trials before it becomes widely available. There are concerns about some porcine virus that can jump onto humans, he says.

 

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As you know the Pig love to find food from garbage and heart transplantation could be very expensive it means only richest person will get Pig's heart and after recovery his family will not allow him to go toward garbage bin so how he will survive?

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