Pfizer booster spurs immune response to new omicron subtypes | amNewYork

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Pfizer said Friday that its updated COVID-19 booster may offer some protection against newly emerging omicron mutants even though it's not an exact match.

FILE – Ryan Dutton, an EMT from Rescue Inc., prepares shots of the Pfizer COVID-19 booster vaccine during a vaccine clinic held by Rescue Inc. at Leland & Gray Middle and High School, in Townshend, Vt., on Tuesday, Sept. 20, 2022. The updated COVID-19 boosters aren’t an exact match to the newest omicron mutants but Pfizer says lab tests suggest its shot may offer some cross-protection.

Americans have been reluctant to get the updated boosters rolled out by Pfizer and rival Moderna, doses tweaked to target the BA.5 omicron strain that until recently was the most common type. With relatives of BA.5 now on the rise, a question is how the new boosters will hold up. The immune response wasn’t as strong against this alphabet soup of newer mutants as it is against the BA.5 strain. But adults 55 and older experienced a nearly 9-fold jump in antibodies against BQ.1.1 a month after receiving the updated booster, according to a study from the University of Texas Medical Branch in Galveston and the companies. That’s compared to a 2-fold rise in people who got another dose of the original vaccine.

The BA.5 variant was responsible for about 30% of new cases in the U.S. as of Nov. 12, according to the Centers for Disease Control and Prevention, but two new variants have been crowding out the once-dominant strain in recent weeks. The BQ.1.1. variant now accounts for 24% of cases, up from 2% in early October and the close cousin BQ.1 accounts for 20% of cases.

 

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Booster offer 'some protection' even though that has never been tested.

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