Maintaining White Matter Integrity via Physical Activity May Help to Offset Age-Related Cognitive Decline
Accumulating evidence suggests that in addition to slowing down gray matter atrophy and the loss of brain volume due to age-related shrinkage, regular physical activity may also help to maintain white matter microstructure integrity as we age. "[Our] analyses are consistent with the notion that brain tissue microstructure, as quantified by postmortem MRI, partially mediates the association between higher levels of physical activity and better cognitive function," Dawe et al. conclude.
That said, like most MRI-based brain imaging studies, the latest paper on"physical activity, brain tissue microstructure, and cognition in older adults" has limitations. Although this study advances our understanding of how"brain tissue microstructure mediates the relation between physical activity and cognition in old age," the researchers acknowledge that more research is needed to"elucidate the molecular mechanisms underlying this pathway.
In terms of future research, the authors note that their recent findings"may help to direct future studies focused on specific brain regions to elucidate the molecular mechanisms underlying this pathway, thereby catalyzing further drug discovery for maintaining cognition."Robert J. Dawe, Lei Yu, Sue E. Leurgans, Bryan D. James, Victoria N. Poole, Konstantinos Arfanakis, Julie A. Schneider, David A. Bennett, Aron S. Buchman.
ckbergland That’s correct
ckbergland Exercise is very important for physical as well as mental health. It should be a part of a comprehensive plan to keep us fit & happy.
ckbergland Took up aerobic exercise in July 1999 to conquer Generalised Anxiety Disorder. I used this for the next 14 years to keep my GAD caged up before it finally disappearing. Still continue with my aerobic exercise to this day
ckbergland Now it is a struggle...
ckbergland You can fortify it all you want, it only takes a couple of hits to knock it out of whack... though it is a good idea to be 'as strong as you can be'...I lost much of that to a stroke in 95, and 5 years of physical illness in 2002. I had been a HEALTHY Martial Artist....
ckbergland 😏
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