Microbiome Alterations Link to Growth Hormone Deficiency

, involved more than 80 children and showed that those with GHD had alterations in microbial populations that have been linked to longevity, as well as a microbial and metabolite signature that allowed accurate discrimination from ISS.

"One of the problems is how you define growth hormone deficiency," as it is"not a black and white diagnosis," and the etiology and child's growth trajectory also need to be considered, Dauber toldDauber explained:"The problem is that, when you rely on the growth hormone stimulation test alone, there's so many false positives and so much overlap between patients with true growth hormone deficiency and those without. And I think that this article fell prey to that.

Dauber continued:"Now, that being said, they did find some associations that correlated with growth hormone peak levels," some which replicate previous findings,"so I do think that there are kernels of important findings here."He pointed out that there are"many factors that influence the microbiome," such as the use of antibiotics, diet, age, and geographic location.

Fecal samples obtained from the children underwent microbiome analysis using 16S ribosomal RNA gene sequencing, alongside nuclear MRI analysis of the metabolome, or the entire complement of small molecules in the samples.The team reports that the alpha diversity of the fecal microbiome, which measures the microbial diversity within a fecal sample, was similar between the three groups.

In addition, the researchers found a decreased Firmicutes/Bacteroidota ratio in participants with short stature, particularly in the GHD group. They noted that"emerging evidence suggests the F/B ratio may play a role in longevity."was characteristic of GHD. The team suggests this"may serve as a critical intestinal factor contributing to the short stature observed in GHD."

Source: Healthcare Press (healthcarepress.net)

GH Deficiency Growth Hormone Deficiency (GHD) GHD - Growth Hormone Deficiency Growth Hormone Microbiome Microbiota Short Stature Children Child Childhood Pediatrics Kids Diversity Hospitals Social Determinants Of Health SDOH Social Determinants Of Health (SDOH) Biologic Therapy Biologics C. Diff Infection Clostridium Difficile Infection

United States Latest News, United States Headlines

Similar News:You can also read news stories similar to this one that we have collected from other news sources.

xCT protein is key link in inhibiting pancreatic cancer growth and limiting mood disturbancesThe xCT protein, which plays an important role as a transport molecule in the cell, could play a part in cancer treatment in the future, researchers have discovered. Their recent studies on mice show that targeting the protein can not only reduce tumor growth, it can also help regulate the inflammatory response and improve mood.
Source: ScienceDaily - 🏆 452. / 53 Read more »

Interior green wall plants treated with antigibberellin plant growth regulators show controlled stem growthAs more businesses recognize the many benefits of having plants in the workplace, interior green walls, also known as living walls, have gained popularity in recent years for their aesthetic appeal and environmental benefits.
Source: physorg_com - 🏆 388. / 55 Read more »

A fecal microbiota transplant may lead to alterations in cognitive function.The impact of the gut microbiome on cognition motivates us to explore ways to manipulate the gut microbiota of psychological patients by transferring microbes from healthy donors.
Source: PsychToday - 🏆 714. / 51 Read more »

What To Eat (& Avoid) For A Healthy Gut, From A Microbiome ExpertFeed your microbes what they crave, and your gut will thrive—quickly. 
Source: mindbodygreen - 🏆 296. / 63 Read more »

If Your Digestive System Is Regular, Daily Probiotics Might Be Doing Your Microbiome a DisserviceWondering if you should take probiotics daily? The risks and benefits aren't the same for everyone. Find out if you really need a probiotic.
Source: iamwellandgood - 🏆 462. / 53 Read more »

Impact of synbiotic supplements on the gut microbiome and overall health of penguinsThe gut microflora plays a pivotal role in the overall well-being of all living organisms. Like their multifaceted and beneficial role in humans, the role of the gut microbiome in maintaining health, behavior, and ecology of animals is unequivocal.
Source: physorg_com - 🏆 388. / 55 Read more »