Managing Respiratory Symptoms in the 'Tripledemic' Era

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Readers weighed in on Dr Charles Vega's approach to a patient whose symptoms could be from COVID-19, flu, or RSV. Tripledemic

, presenting with fever, cough, myalgia, and fatigue. I asked readers whether they agreed with my management of this patient.

These costs are prohibitive for many health systems. However, more devices have been introduced since that analysis, and competition and evolving technology should drive down prices. Generally, multiplex polymerase chain reaction testing for multiple pathogens is less expensive than ordering two or three separate molecular tests and is more convenient for patients and practices alike.

However, if just 2% of the population of 1000 has the infection in this same scenario, then only 18 true cases are identified. The effect on public health is certainly less, and a lower prevalence rate means that confounding variables, such as how long an individual might shed viral particles and the method of sample collection, have an outsized effect on results. This reduces the validity of diagnostic tests.

of 29 randomized controlled trials of over-the-counter medications for cough yielded mixed and largely negative results.was successful in only one of three trials. Combinations of different drug classes appeared to be slightly more effective.

 

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