Takahashi's zeal to grow a new set of teeth on demand might sound like a scientific excess when more straightforward approaches like brushing twice a day, flossing, and mouthwash exist in abundance to protect permanent teeth.that ail us. Anodontia, for instance, is a disorder where individuals cannot grow a complete set of teeth.
Takahashi studied dentistry but was also interested in the underlying genetics of these conditions, so studied molecular biology at Kyoto University and in the US.Researchers have begun making links between dental conditions and various genes. One research group found that mice grew fewer teeth when specific genes were deleted. On his return from the US, Takahashi's team at Kyoto University found that mice lacking a gene had more teeth.
Takahashi's team then developed an antibody that could target the USAG-1 protein. The antibody was trialed in mice in 2018 and showed new teeth coming through. The team then replicated its research in ferrets with dental patterns similar to humans. These findings were then published in 2021, which received global acclaim as a "Now the research team is working to get the antibody into human clinical trials, which are scheduled to begin in July 2024. The antibody will be administered to children between the ages of two and six affected by anodontia.
If the trials go as per plan, it will open up a whole new world of dental treatments which rely on synthetic dentures and implants.
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