Is long COVID forever? A new study has clues.

suggests that by 24 months, signs of heightened immune activity in most long-COVID patients will have returned to normal levels. Pictured above is a composite colored scanning electron micrograph of immune cells—including a single macrophage, two dendritic cells, and numerous white blood cells—involved in a cytokine storm, a life-threatening immune disorder. Cytokines are important for normal immune response, but when too many are released simultaneously it can be harmful.

"It looks like those people's immune systems have largely returned to what we would expect," says Gail Matthews, an infectious disease physician at St Vincent's Hospital, Sydney, who led the study. "And that's really good." "It was quite surprising for us to see that even after mild to moderate COVID-19, the inflammatory biomarkers were high up until eight months for long COVID patients," says Chansavath Phetsouphanh, an immunologist at the Kirby Institute, UNSW Sydney. Phetsouphanh led the study that first hinted at ain people who had long COVID compared to those who had been infected with SARS-CoV-2 and fully recovered.

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