, a precursor of elastin that’s identical to what’s found in human tissues. Think of it like a next-level retinoid, feeding skin what it needs to produce more plumping proteins. “This is a completely human-based molecule,” Hausauer says, underscoring, yet again, a shift to injectable ingredients that are native to our bodies.
Imagine a needle penetrating the nuclei of your skin cells to replace or reprogram the pesky gene responsible for your deepening crow’s feet or crepey neck.
In order to target fine lines and improve the quality of the skin, Hausauer notes, the gene has to be placed high up in the dermis, “where your body has the machinery to translate it.” If this gene-based treatment is eventually approved—phase two trials are expected to start in 2023—she envisions using it in a skin-boosting fashion, dotting tiny doses across the treatment area to create a sweeping change.
“Neuromodulators are a game-changer treatment with a multitude of effects through various signaling pathways,” Sundaram tells us. “There is growing evidence that this includes regenerative effects on the skin, through the stimulation of new collagen and elastin production, which explains the progressive improvement in skin quality and elasticity that we see in patients who continue their neuromodulator treatments over years or decades.
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