First monkeypox genome from latest outbreak shows links to 2018 strain

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Scientists are racing to understand the outbreak of monkeypox in a number of countries around the world, and have now published the first draft genome, taken from a patient in Portugal

at Icahn School of Medicine at Mount Sinai, New York, says the draft sequence from Portugal has too many gaps to draw firm conclusions, but that he has seen a more complete sequence from a team in Belgium. “As far as I can see, it seems to be identical to the one in the UK in 2018,” says Palacios. “That is a little bit odd.”

In 2018, there were three cases in the UK after someone returning from Nigeria infected two other members of their household. As more samples are sequenced, it should become clear whether, as suspected, a single variant of monkeypox is responsible for all the cases in the latest outbreak. But establishing whether there is something unique about this variant won’t be easy. Even with the now, it is hard to link particular mutations to changes in viral transmissibility and so on. The monkeypox virus is much larger – around 200,000 DNA letters long compared with 30,000 RNA letters for the coronavirus – and for now at least not nearly as intensively studied.

 

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Have they asked Bill Gates yet? I remember him hinting at next pandemic soon.

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