They lifted the hold a week later, but it has continued in the American arm of the study.
There are 49 COVID-19 candidate vaccines in clinical trials around the world, nine of which are in large, late-stage studies, Barrett said. Only three people out of the roughly 300,000 volunteers in all those trials are known to have suffered serious side effects. “It’s not a big number,” he said. In the United Kingdom, where the volunteer lived, regulators examined her case and decided the trial could resume. The U.S. Food and Drug Administration kept the U.S. trial on hold as it investigates her case.
A tiny number of people who are naturally sickened with adenovirus develop transverse myelitis, a neurological disorder of the spine that can cause paralysis.“Nobody knows why it happens, but it appears to be some type of immune response. Perhaps the immune system is reacting to the virus, and that’s causing a cross-reaction,” Yang said.
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