DOJ Reportedly Opens Criminal Inquiry Into Alzheimer's Research

Alicia Ault and David Warmflashopened a criminal investigation into Cassava Sciences just 1 week after a neuroscientist alleged in an expose that the company's studies of the experimental Alzheimer's drug simufilam appeared to include altered images.

A Reuters news story reported that the DOJ had opened an investigation that would be overseen by DOJ staff who investigate fraud against investors, consumers, and the federal government. The DOJ did not return a request for comment by press time. The department does not generally comment on investigations.that no charges have been filed against the company and that allegations of research misconduct are false.

"No government agency has informed us that it has found supporting evidence of research misconduct or any other wrongdoing and for good reason ― there is no supporting evidence for allegations of research misconduct," he said.Based in Austin, Texas, Cassava has been surrounded by controversy almost since its start in 2019.

Most recently, Matthew Schrag, MD, PhD, an Alzheimer's researcher with Vanderbilt University Medical Center in Nashville, Tennessee, alleged in an expose in the journalthat it appeared Cassava's research included altered or duplicated brain images that have appeared in dozens of journal articles supporting the efficacy of simufilam. Schrag filed a whistleblower report with the National Institutes of Health, which has spent millions funding the drug's development.

He added that despite these limitations, he believes"there's enough here that it's important for regulatory bodies to take a closer look at it to make sure that the data is right."feature article described how Schrag was hired in August 2021 by the law firm Labaton Sucharow to analyze Cassava studies for aLabaton Sucharow wanted the FDA to put a hold on Cassava's trials until alleged irregularities in the research could be investigated.

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