This is not the first study to point out these side effects of chlorthalidone, the study authors said.
He added that both drugs seem equally effective and are both inexpensive."The good news is that the better choice is the most commonly prescribed diuretic for hypertension," Krumholz said."The evidence is strong, but it is not a clinical trial, so there remains some uncertainty," Krumholz said."But until stronger evidence is out, this study represents some of the best information we have -- and it favors hydrochlorothiazide.
Fortunately, Fonarow said, a large randomized trial comparing these drugs is underway with a plan to enroll 13,500 people with high blood pressure. Results are expected in 2022.
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