Mouse sensory neurons are shown in magenta. BH4, the molecule driving chronic pain, is shown in green. Hence, the neurons “in pain” are seen in green/white. Credit: ©Cronin/IMBA
Acute pain is an important danger signal. On the other hand, chronic pain is based on persistent injury and can even be experienced in the absence of a stimulus, injury, or disease. Despite the fact that hundreds of millions of people are affected, chronic pain is among the least well-managed areas of healthcare.
To identify drugs that reduce BH4 levels in pain neurons, the scientists performed a “phenotypic screen” of 1000 target-annotated, FDA-approved medications. This approach allowed the researchers to start their search using medications that are currently in use for various indications, and to identify undescribed, off-target analgesic properties.
Source: Healthcare Press (healthcarepress.net)
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