Akira Endo, the Father of Statins, Dies

Akira Endo, PhD, the Japanese microbiologist and biochemist known as the father of statins, died at the age of 90 on June 5. His research led to the discovery and rise of a class of drugs that revolutionized the prevention and treatment of cardiovascular disease s. This scientific journey began over half a century ago.Born into a family of farmers in northern Japan, Endo was fascinated by natural sciences from a young age and showed a particular interest in fungi and molds.

In July 1973, they isolated three active metabolites from this mold, one of which was compactin, which had structural similarities to HMG-CoA, the substrate of the HMG-CoA reductase reaction. However, researchers faced a second challenge in April 1977. Microcrystalline structures were detected in the liver cells of rats that had been fed extremely high amounts of compactin . Initially deemed toxic, the structures were ultimately found to be nontoxic.

Source: Healthcare Press (healthcarepress.net)

Lipid Management Statin Lipid Lowering Drugs Cardiovascular Disease Cvd - Cardiovascular Disease CV Risk Cardiovascular Risk CV Risk Factors Cardiovascular Risk Factors Cardiovascular Risk Management Healthcare And Medical Technology Health And Medical Tech Health And Med Tech Health And Medical Technology Healthcare Technology Medical Technology Toxicology Toxicity

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