Peter Wolynes’ team at Rice University uncovered how pseudogenes evolve and affect protein folding, revealing unexpected mutation effects. Their study highlights the potential for some pseudogenes to regain protein-coding abilities, with implications for protein engineering. . Credit: SciTechDaily.comPeter Wolynes and his research team have made a significant breakthrough in understanding the evolution of specific genetic sequences known as pseudogenes.
However, the researchers observed instances where certain mutations unexpectedly stabilized the folding of pseudogenes at the cost of altering their previous biological functions. Using sophisticated computational models, the researchers interpreted the interplay between physical folding landscapes and the evolutionary landscapes of pseudogenes. Their findings provide evidence that the funnel-like character of folding landscapes comes from evolution.
Source: Tech Daily Report (techdailyreport.net)
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