, I've been on the lookout for science-based evidence that gives us fresh clues about how to trigger the release of feel-good neurotransmitters on demand via exercise and day-to-day lifestyle habits.of mice reports that in addition to dopamine being released after achieving a goal, dopaminergic activity can be"ramped up" willfully when a treadmill-running mouse is trained to receive a reward for learning to modulate its"spontaneous impulses" of dopamine on demand.
Foo et al.'s ultimate goal was to answer the research question:"Can mice be trained to change the amplitude and/or timing of dopamine events triggered by internal brain dynamics, much as they can change the amplitude and timing of dopamine impulses based on an external cue?" In this experiment, willfully increasing dopamine while running on a treadmill was reinforced with the prize of a"sucrose drop reward." Real-time feedback of how a mouse's brain responded to these rewards made it possible to teach mice how toAfter just a few practice sessions, the researchers found that trained mice could volitionally modulate spontaneous dopamine impulses while moving on a treadmill.
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