By Neha MathurApr 24 2023Reviewed by Lily Ramsey, LLM In a recent study published in the JAMA Network Open Journal, researchers conducted a systematic review and meta-analysis among epilepsy patients to evaluate cannabidiol use-related adverse events , including their frequency and risk.
Although prior studies have examined CBD's effectiveness and safety profile, there is a lack of systematic reviews reporting AEs related to CBD use in epileptic patients or addressing the limitations of previously published reviews. Two other independent reviewers extracted all the basic data from each article in the study. Notably, they included randomized clinical trials evaluating a minimum of one AE related to CBD use in epileptic patients.
If AEs for at least one arm were zero, the team used a continuity correction of 0.5. They evaluated publication bias only when ten studies were included, with p<0.05 considered statistically significant. Most of the included studies were multicenter RCTs published between 2017 and 2022, with participants aged ~1 to 57 years. The epileptic patients had various forms of epilepsy, e.g., Tuberous sclerosis–associated epilepsy.
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