Vitamin D receptor polymorphism found to influence COVID-19 severity

By Dr. Sushama R. Chaphalkar, PhD.May 7 2024Reviewed by Lily Ramsey, LLM In a recent case-control study published in Scientific Reports, researchers compared single nucleotide polymorphisms in the vitamin D receptor gene between mild and severe coronavirus disease 2019 patients.

VDR gene polymorphisms affecting VDR function are associated with immune responses. In COVID-19 patients, various VDR polymorphisms correlate with different symptoms, such as shortness of breath, renal disease, and hypertension. Genetic variations in the vitamin D pathway influence susceptibility to respiratory infections.

Eligible patients aged 19 years and above with positive RT-PCR results were selected using convenience sampling from provincial health center datasets. Patients' medical histories, including non-communicable diseases such as cardiovascular disease, hypertension, diabetes mellitus, chronic respiratory disease, chronic kidney disease, and medication history, were obtained.

Among the SNPs studied, the TT genotype of rs11568820 was found to be significantly rare in the hospitalized group compared to the non-hospitalized group .

Source: Healthcare Press (healthcarepress.net)

Covid-19 Receptor Vitamin D Chronic Coronavirus Diabetes Diabetes Mellitus DNA Gene Genetic Lungs Nucleotide Pneumonia Renal Disease Research Respiratory Single Nucleotide Polymorphisms

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