Apr 12 2024University of Geneva Cells contain various specialized structures - such as the nucleus, mitochondria or peroxisomes - known as "organelles''. Tracing their genesis and determining their structure is fundamental to understanding cell function and the pathologies linked to their dysfunction. Scientists at the University of Geneva have combined high-resolution microscopy and kinematic reconstruction techniques to visualize, in motion, the genesis of the human centriole.
Inflating cells for better observation This is particularly true of the centriole. This organelle, measuring less than 500 nanometers , is constituted of around 100 different proteins organized into six substructural domains. Until a few years ago, it was impossible to visualize the structure of the centriole in detail.
Reorganizing images to set them in motion ''This very tedious work was followed by a pseudo-temporal kinematic reconstruction. In other words, we were able to put these thousands of images taken at random during centriole biogenesis back into chronological order, to reconstruct the various stages in the formation of centriole substructures, using a computer analysis we developed,'' explains Virginie Hamel, co-leader of the study.
Cell Microscopy Mitochondria Organelle Research
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