Mar 15 2024Children's Hospital of Philadelphia Researchers from Children's Hospital of Philadelphia identified a key metabolite in cells that helps direct immune responses and explains at a single cell level why immune cells that most efficiently recognize pathogens, vaccines, or diseased cells grow and divide faster than other cells.
However, the underlying mechanisms as to why high affinity immune cells respond more efficiently have remained a mystery for researchers. After seeing an antigen, the chemistry inside T and B cells needs to change to allow them to properly respond. The researchers in this study wanted to look at metabolism to understand what causes high affinity cells to know that they need to divide more quickly to respond appropriately.
Will Bailis, PhD, Senior Study Author, Assistant Professor of Pathology and Laboratory Medicine at CHOP and the Perelman School of Medicine of the University of Pennsylvania Additionally, the researchers found that manipulating how much NAD a cell was allowed to make could control when that cell went from a resting state to wanting to divide, suggesting that the metabolite could be used to improve response in certain T cell-driven therapies or vaccines.
We have summarized this news so that you can read it quickly. If you are interested in the news, you can read the full text here. Read more:
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
AI Tool Boosts Diagnosis Accuracy of Ear Infections in Children, Study FindsResearchers developed and validated an automated classifier for diagnosing acute otitis media (AOM) in children.
Source: NewsMedical - 🏆 19. / 71 Read more »
Researchers discover key metabolic process responsible for rapid immune responsesResearchers from Children's Hospital of Philadelphia (CHOP) identified a key metabolite in cells that helps direct immune responses and explains at a single cell level why immune cells that most efficiently recognize pathogens, vaccines, or diseased cells grow and divide faster than other cells.
Source: medical_xpress - 🏆 101. / 51 Read more »
Measles outbreak in Lancashire confirmed as parents urged to get kids vaccinated'One in five children will need a hospital visit if they become unwell'
Source: LiveLancs - 🏆 10. / 87 Read more »
Researchers develop shortcut to generate brain stem cells for age-related disease researchA research team from the School of Biomedical Sciences, LKS Faculty of Medicine of the University of Hong Kong (HKUMed), has achieved a breakthrough in stem cell research, offering tools that can be used for patients who require highly personalized care.
Source: medical_xpress - 🏆 101. / 51 Read more »
Gigi Hadid Has Signed Off The Flicked Bob As Spring's Fashion ChopHere's how to style it.
Source: GlamourMagUK - 🏆 2. / 98 Read more »
Researchers gain insight into why T cells lose energy in solid tumorsT cells are often called 'assassins' or 'killers' because they can orchestrate and carry out missions to hunt down bacteria, viruses, and cancer cells throughout the body. Mighty as they may be, recent research has shown that once T cells infiltrate the environment of a solid tumor, they lose the energy needed to combat the cancer.
Source: medical_xpress - 🏆 101. / 51 Read more »