University of Cincinnati to lead NIH StrokeNet for next five years

Created in 2013, NIH StrokeNet conducts clinical trials and research studies to advance acute stroke treatment, prevention, and recovery and rehabilitation following a stroke. The national network includes 27 regional coordinating centers or hubs associated with over 200 hospitals enrolling in its trials.

Also new to NIH StrokeNet, the neuroimaging team led by Achala Vagal, MD and Vivek Khandwala, PhD, will be formally named as the NIH StrokeNet Imaging Management Center. Their activities have already brought efficiency and expertise to developing the imaging aspects of trial designs, and collecting and analyzing brain images worldwide.

Since 2013, more than 11,000 patients have been enrolled in NIH StrokeNet trials. These studies have led to significant advances in patient care worldwide. As an example, the DEFUSE-3 study published in 2018 improved acute stroke care by demonstrating that endovascular therapy resulted in better long-term outcomes than medical therapy alone for acute ischemic stroke patients beyond conventional time windows with at-risk brain tissue. The study received a U.S.

Related Stories"Clinical outcomes have advanced dramatically in the last decade, thanks to clinical trials that test what works and what does not in systematic and careful ways across the range of people who would receive them," Khatri said. "Moreover, these advancements are made possible by the patients who decide to participate in clinical trials. I am especially excited that we have found ways to do our trials more efficiently to speed up our pace of advancing stroke care.

UC and UC Health's role as the StrokeNet National Coordinating Center also includes pharmacy and single institutional review board services, and contract management with all clinical trial sites for the network. The NIH StrokeNet Research Pharmacy at UC Health led by Noor Sabagha, PharmD, has shipped more than 12,000 study drugs to US trial sites, and guided drug-related study design and management worldwide, for the past five years.

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