Successful murine model of dermatomyositis reveals underlying immune system involvement

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Some diseases involve autoimmune reactions when the body begins to attack its own cells and proteins. The biological mechanisms underlying these diseases are often unknown, making treatment challenging. Now, a group at TMDU has created a murine model for a disease known as 'anti-MDA5 antibody-positive dermatomyositis.

Successful murine model of dermatomyositis reveals underlying immune system involvement. Credit: Department of Dermatology, TMDU

The research team went on to identify elevated levels of a signaling molecule called interleukin-6 in the murine model."Experimental reduction of interleukin-6 levels ameliorated the development of ILD," explains senior author Dr.

: Successful murine model of dermatomyositis reveals underlying immune system involvement retrieved 11 April 2024 from https://medicalxpress.com/news/2024-04-successful-murine-dermatomyositis-reveals-underlying.html

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