By Susha Cheriyedath, M.Sc.May 29 2024Reviewed by Lily Ramsey, LLM In a recent systematic review published in Current Issues in Molecular Biology , researchers from Portugal examined and discussed the role of oxytocin in polycystic ovary syndrome , its association with PCOS symptoms, and the effect of OT administration.
PCOS is linked to high levels of androgen and abnormal LH/FSH ratios, contributing to anovulatory infertility and increased risks during pregnancy. Despite these findings, the exact role of OT in PCOS remains unclear. In the present systematic review, researchers aimed to clarify OT's role in PCOS by examining all the relevant animal and human studies.
Results and discussion Cohen’s kappa value was found to be 0.742, indicating significant agreement between the two individual reviewers. The human studies primarily explored the relationship between OT administration and fertility. The animal studies used rat models to assess the effects of OT on metabolic disorders and uterine function. One study found that OT administration regulated uterine contractions in PCOS rats, while another reported that acute OT administration could reduce body weight and food intake in PCOS rats.
Polycystic Ovary Syndrome Syndrome Amino Acid Androgen Endocrine Fertility Food Genetic Hormone Infertility Molecular Biology Ovaries Pregnancy Research
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