Apr 13 2024Pohang University of Science & Technology This approach advances our ability to pinpoint proteins essential for organelle interactions within specific spatial and temporal contexts.
Emerging from this need, a novel strategy called "OrthoID" has been developed through the collaborative efforts of scientists from POSTECH, Daegu Catholic University School of Medicine, and Seoul National University. Featured in Nature Communications, OrthoID addresses this challenge by refining our ability to identify proteins that act as mediators in these critical conversations.
Through meticulous experiments, the researchers have demonstrated the efficacy of OrthoID in rapidly and accurately labeling proteins involved in the dynamic processes of organelle communication. By leveraging proximity labeling techniques with orthogonal binding pair systems, the method effectively labeled and isolated proteins facilitating the critical interactions between mitochondria and ER.
Source: Education Headlines (educationheadlines.net)
Organelle Calcium Cellular Biology Lipids Medicine Mitochondria Protein Protein Labeling Research Technology
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