By Pooja Toshniwal PahariaJan 16 2023Reviewed by Danielle Ellis, B.Sc. In a recent study posted to the bioRxiv* preprint server, researchers evaluated the use of receptor decoys for severe acute respiratory syndrome coronavirus 2 based on soluble forms of angiotensin-converting enzyme 2 for immunological prophylaxis and management of coronavirus disease 2019 through the use of adeno-associated virus vectors.
About the study In the present study, researchers applied the vectored immunological prophylaxis concept to establish long-term COVID-19 prophylaxis by lentiviral and AAV vectors expressing a modified high-affinity ACE2 microbody. Luciferase activity in cell cultures was evaluated at 2.0 days post-infection . The ability of the decoy-expressing vectors to inhibit SARS-CoV-2 live virus replication was tested on A549.ACE2, CHME3.ACE2 and the hSABCi-NS1.1 human small airway basal cells.
Results Intramuscular or intranasal administration of ACE2.1mb-expressing AAV6.2 and AAV2.retro vectors conferred a high degree of protection against COVID-19 in BALB/c mice and ACE2 K18 transgenic mice. Lentiviral- and AAV-vectored immunological prophylaxis were durable and effective against the recently emerged Omicron sub-VOCs. In addition, the vectors showed therapeutic efficacy when delivered ≤1.
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