By Pooja Toshniwal PahariaJan 31 2023Reviewed by Danielle Ellis, B.Sc. In a recent study published in Science Immunology, researchers investigated the CAMCI strategy as an immunotherapeutic option for inflammatory bowel disease .
Further, the team investigated the effects of MEP1-driven CD4+ T lymphocyte activation and mTOR inhibition on CD4+ TE metabolism and CD4+ regulatory T lymphocyte functions in the in vitro setting and in vivo setting. Next, the team evaluated the cumulative impact of antigen-targeted helper TE suppression and Treg activation with mTOR suppression on gut inflammation intensity using adoptively transferred naïve CBir1 T cell receptor transgenic CD4+ T lymphocytes in RAG1−/− murine animals.
The team investigated whether metformin, an adenosine monophosphate-activated protein kinase pathway activator, with or without rapamycin could robustly inhibit CD4+ TM cells. They also investigated if the CAMCI approach could be used in humans and ablate disease-causing microbiome-reactive CD4+ T lymphocytes in circulation. For the investigation, PMBCs obtained from Crohn’s disease patients were stimulated with Lachnospiraceae flagellin antigens such as CBir1, A4 Fla3, FlaX, and 14-2 Fla1.
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