Oral semaglutide shows significant promise in improving diabetes control and cardiovascular health, study reveals

By Dr. Priyom Bose, Ph.D.May 29 2024Reviewed by Benedette Cuffari, M.Sc. A recent Journal of Clinical Medicine study investigates the efficacy of oral semaglutide in patients with type 2 diabetes .

The PIONEER program was conducted to determine the effectiveness of oral semaglutide in patients at different stages of diabetes. Depending on the stage of diabetes, patients received either monotherapy or multiple doses of oral glucose-lowering agents. Based on the findings of the PIONEER program, the United States Food and Drug Administration supported the safety and efficacy of oral semaglutide in 2019, followed by approval from the European Medicines Agency in 2020.

About the study The current retrospective study was conducted at two university-based diabetes centers in Italy. Data were obtained from an electronic chart system software created by Italian diabetes outpatient clinics to manage patients’ medical history. Study findings In a routine clinical setting, patients treated with initiating oral semaglutide doses exhibited sub-optimal metabolic control and short diabetes duration. However, a significant clinical improvement in HbA1c levels and a reduction in BW were achieved after six months of treatment. These improvements were primarily observed in recently diagnosed patients with diabetes, thus demonstrating the effectiveness of oral semaglutide in the early stages of the disease.

Before receiving oral semaglutide treatment, study participants had already undergone treatment with sodium-glucose cotransporter-2 inhibitors , basal or fast-acting insulin, GLP-1RA, pioglitazone, metformin, DPP4i, or sulfonylureas for T2D. During the study period, at six months of oral semaglutide treatment, most patients received seven mg semaglutide, whereas only 2% received the 14 mg dose.

Source: Healthcare Press (healthcarepress.net)

Semaglutide Type 2 Diabetes Agonist Blood Blood Pressure Efficacy Food Glucagon Glucagon-Like Peptide-1 Glucose Glycemic Index Hba1c Medicine Receptor

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