Novel Nanoplatform Found Effective Against Esophageal Cancer

By Dr. Priyom Bose, Ph.D.Aug 10 2022Reviewed by Megan Craig, M.Sc. Among the total number of deaths caused by different types of cancer, esophageal cancer is the sixth most significant. Several conventional treatments, such as radiotherapy, chemotherapy, and surgery have multiple side effects, including off-target toxicity and multidrug resistance .

Scientists sought to address these limitations of the existing therapies and developed a novel theranostic nanoplatform, namely, GCDs-Ce6/Pt-EGF, which has been found to be effective against esophageal cancer. This study has been recently published in Biomedicine & Pharmacotherapy. Two of the limitations associated with photothermal therapy and oxidative therapy are the recurrence of tumor cells and damage caused to off-target non-cancerous cells as well. PDT is effective against different types of cancers, such as breast, prostate, liver, and esophagus, with a better biosafety effect. However, its effectiveness is compromised by abundant glutathione in the tumor microenvironment and hypoxia.

A Novel Theranostic Nanoplatform for Esophageal Cancer Treatment Recently, scientists have developed an all-in-one theranostic nanoplatform, known as GCDs-Ce6/Pt-EGF for esophageal cancer treatment. This nanoplatform utilized green fluorescence carbon dots , which were synthesized using p-aminosalicylic acid and p-aminobenzamide with a molar ratio of 1:1 at 200℃ for 6 hours, via the hydrothermal method.

Post irradiation at 660 nm wavelength, photosensitizer Ce6 induced cell death by generating reactive oxygen species . This phenomenon induced tumor cell apoptosis. Both in vitro and in vivo studies strongly indicated that the GCDs-Ce6/Pt-EGF exhibited superior photodynamic properties and could be effectively applied for esophageal tumor imaging as well as the elimination of esophageal cancer cells .

United Kingdom Latest News, United Kingdom Headlines

Similar News:You can also read news stories similar to this one that we have collected from other news sources.

Grease star Dame Olivia Newton-John dies aged 73She had breast cancer R.I.P. our Sandra Dee 💔 RIP Sandy ❤️ RIP ONJ. Love your film grease. Love to JT and all who knew Olivia xxx
Source: nottslive - 🏆 96. / 52 Read more »

'I've been let down - I shouldn't have stage-4 cancer''This is an absolute disaster' Imperial College London's prof_price tells Newsnight delays in care is the worst cancer crisis she's seen in her lifetime. 📺 Full report tonight on BBC 2 at 22.30 PT1-My partner had a scan for a growth on her Thyroid early this year which showed it had doubled in size over the last six months. When she asked what do we do next, she was told that they wouldn’t do anything as it was only at 1cm and the other grows were smaller. PT2 - When she asked what do we do next, she was told ‘When you have problems swallowing or breathing, then come back’…..utterly ridiculous. Fortunately, she was able to go back to Portugal where her mum still lives, and have a biopsy done that week due to urgency and concern. prof_price Bankrupted ourselves and saved the NHS at least though, so was all worth it.
Source: BBCNewsnight - 🏆 109. / 51 Read more »

Visionary Designer Issey Miyake Has DiedThe celebrated Japanese designer has passed away of cancer, aged 84
Source: AnOtherMagazine - 🏆 97. / 51 Read more »

Man fought to get late granny's treasured possessions following house firePaddy Bennett was arrested after arriving home to find his late grandmother's house ablaze
Source: BelfastLive - 🏆 16. / 77 Read more »

Newscast - Tooth be Told - BBC Sounds➡️Nine in 10 practices not seeing new patients ➡️DIY dental jobs on the rise ➡️Is NHS dentistry in crisis? Hear more on the latest BBCNewscast
Source: BBCNews - 🏆 3. / 97 Read more »