Newly discovered lincRNA controls the development and function of regulatory T cells

May 30 2024Turun yliopisto

The scientists at Turku Bioscience Centre have now discovered a novel RNA that controls the development and function of regulatory T cells. This long intergenic noncoding RNA modulates the levels of transcription factor FOXP3 and the suppressive function of human regulatory T cells by controlling the interleukin-2 receptor. The finding potentially enables the development of new therapeutic approaches to control the human immune response.

Our discovery provides a basis for developing precision medicine treatments for autoimmune diseases and cancer. Regulatory T cells are already being studied in patients to treat type 1 diabetes, and our novel lincRNA molecule could, for example, be used to boost the production of these cells for therapeutic use." The discovery is particularly interesting because cancer cells are able to hide from the immune system by specifically manipulating regulatory T cells.

Expression of lincRNAs is highly tissue and cell-specific so targeting these molecules will enable precision therapy against desired targets. The research has been funded by the Jane and Aatos Erkko Foundation, the Research Council of Finland and the Sigrid Jusélius Foundation. The research article was published in the esteemed PNAS journal.Journal reference:Andrabi, A., et al. . Long noncoding RNA LIRIL2R modulates FOXP3 levels and suppressive function of human CD4. PNAS. doi.org/10.1073/pnas.2315363121.

Source: Healthcare Press (healthcarepress.net)

Bacteria Blood Cancer Molecule Research RNA

United Kingdom Latest News, United Kingdom Headlines

Similar News:You can also read news stories similar to this one that we have collected from other news sources.

How we put specific allegations to Kevin SpaceyThe double Oscar-winner’s team said he would reply by Thursday lunchtime. Then he missed three deadlines
Source: i newspaper - 🏆 8. / 89 Read more »

Slot reveals likelihood of signing specific players at Liverpool as he seeks Klopp adviceFeyenoord boss Arne Slot insists that 'if a player is good, it shouldn’t matter what level he comes from' amid rumours linking Liverpool with his stars.
Source: F365 - 🏆 5. / 97 Read more »

Study highlights need for cell-type-specific therapies in treatment of HIVResearchers from the University of Illinois have demonstrated the importance of cell-type-specific targeting in the treatment of HIV.
Source: medical_xpress - 🏆 101. / 51 Read more »

No ‘specific isolation facilities’ in Northern Ireland at pandemic outbreakThe Department of Health had sought help to find suitable premises.
Source: Glasgow_Times - 🏆 76. / 59 Read more »

No ‘specific isolation facilities’ in Northern Ireland at pandemic outbreakThe Department of Health had sought help to find suitable premises.
Source: Observer_Owl - 🏆 18. / 72 Read more »

Nvidia PUE-PUEs datacenter efficiency ratings, calls for application-specific metricsWhat good is great power use effectiveness if your DC is packed with inefficient kit?
Source: TheRegister - 🏆 67. / 61 Read more »