Key transport systems fuel rapid E. coli growth in UTIs

May 3 2024Michigan Medicine - University of Michigan

Investigators working in the lab of Harry Mobley, Ph.D., at the University of Michigan Medical School began by looking at mutant strains that weren't as good at replicating in mouse models to identify bacterial genes that may be important for establishing infection."When bacteria need something to grow, say an amino acid, they can get it in two ways," explained Mobley, who is the Frederick G. Novy Distinguishes Professor of Microbiology and Immunology.

Related StoriesFirst author Allyson Shea, Ph.D., a former member of Mobley's lab and now assistant professor of Microbiology and Immunology at the University of South Alabama, cross-referenced a library of transport proteins from E. coli against other species of UTI pathogens to see which were important for infection. She discovered that a type of transporter called ABC transporters appeared to be critical.

The findings, Mobley notes, open avenues for the development of new therapeutics-;which is especially important in an era of increasing antibiotic resistance.

Anatomy Bacteria Bladder Cell Genes Immunology Microbiology Nutrients Ph Research Toxins

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