Ketogenic diets linked to cellular aging in vital organs, new study finds

By Dr. Chinta SidharthanMay 20 2024Reviewed by Susha Cheriyedath, M.Sc. In a recent study published in the journal Science Advances, a large team of researchers in the United States examined the detrimental effects of ketogenic diet s. The study used murine models and reported that ketogenic diet s can cause cellular senescence in various organs, such as the kidneys and heart. This cellular senescence is dependent on adenosine monophosphate-activated protein kinase and tumor protein 53 .

Studies using murine models have also reported that ketogenic diets could have anti-inflammatory effects and be beneficial against obesity, metabolic, and neurological phenotypes. However, other studies have reported that the low-carbohydrate content of ketogenic diets results in pro-inflammatory effects and increases the risk of kidney damage and cardiac fibrosis.

Approximately six-week-old mice were randomly assigned to a control diet group or the ketogenic diet group. The control group's calorific content was 17% fats and 58% carbohydrates. In comparison, the calorific percentages of the two ketogenic diets were 90.5% fats and only 0.3% carbohydrates. The ketogenic diet here was Crisco-based and had approximately 84% unsaturated fats.

Related StoriesThe tissues harvested from the mice were subject to a wide range of analyses such as immunohistochemistry, western blotting, extraction of ribonucleic acid and messenger RNA expression analysis, chromatin immunoprecipitation, total RNA sequencing, caspase-2 enzyme activity assay, and enzyme-linked immunosorbent assays.

Adenosine Anti-Inflammatory Butter Cancer Carbohydrate Diet Enzyme Epilepsy Fibrosis Heart Ketogenic Diet Kidney Kinase Liver Obesity Protein RNA RNA Sequencing Tumor Weight Loss

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