Ketogenic diet a potential therapy for autism by reshaping gut bacteria and brain inflammation

By Vijay Kumar MalesuMay 9 2024Reviewed by Benedette Cuffari, M.Sc. In a recent study published in the journal Nutrients , researchers explore the impact of a modified ketogenic diet on gut microbiota, inflammatory markers, and brain-related micro ribonucleic acid in children with autism spectrum disorder and its correlation with improvements in behavioral symptoms.

Children with ASD often experience unique T-cell activation and prevalent gastrointestinal issues, thus suggesting a disrupted gut microbiome. Dietary approaches like the KD, which increases blood ketone levels, have shown promise in improving symptoms by potentially offering neuroprotective benefits through the gut-brain axis. However, the interactions between gut microbiota, ketone bodies, and butyrate require further research to develop effective therapies.

Blood samples were processed to separate plasma and cells, with plasma stored at -80°C. Stool samples were collected using a prescribed system, stored in a stabilization solution, and processed for deoxyribonucleic acid and RNA extraction. The analysis included polymerase chain reaction amplification, sequencing for microbial diversity, and quantitative PCR for gene expression.

Study findings Throughout the four-month study period, stool and blood samples were provided for analysis before and after the diet. To confirm the physical state of ketosis, plasma levels of ketone bodies were measured through an enzyme-linked immunosorbent assay assay. To this end, a significant increase in the ketone bodies, acetoacetic acid, and hydroxybutyric acid was observed, thus indicating that the KD was effectively altering metabolism.

Source: Healthcare Press (healthcarepress.net)

Brain Children Cytokines Diet Ketogenic Diet Microbiome Assay Blood Cell Cytokine DNA Inflammation Ketosis Micro Nutrients Protein Research Ribonucleic Acid RNA T-Cell

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