Treatment options for Alcohol Use Disorders have minimally advanced since 2004, while the annual deaths and economic toll have increased alarmingly. Phosphodiesterase type 4 is associated with alcohol and nicotine dependence. PDE4 inhibitors were identified as a potential AUD treatment using a novel bioinformatics approach. We prioritized a newer PDE4 inhibitor, apremilast, as ideal for repurposing, , and tested it using multiple animal strains and models, as well as in a human Phase IIa study.
We found that apremilast reduced binge-like alcohol intake and behavioral measures of alcohol motivation in mouse models of genetic risk for drinking to intoxication. Apremilast also reduced excessive alcohol drinking in models for stress-facilitated drinking and alcohol dependence.
We have summarized this news so that you can read it quickly. If you are interested in the news, you can read the full text here. Read more:
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
JCI - Type 2 diabetes candidate genes, including PAX5, cause impaired insulin secretion in human pancreatic islets
Source: medical_xpress - 🏆 101. / 51 Read more »
F1 2023 pre-season testing guide: Schedule, driver line-ups and how to live streamThe F1 teams will hit the track in Bahrain on Thursday for the start of the one and only three-day pre-season test.
Source: Planet_F1 - 🏆 126. / 51 Read more »
UK games revenue declined in 2022, but still well up on pre-pandemic levels | VGCUK spending on video games reportedly declined in 2022 for the first time in ten years, but the market was still well up on pre-pandemic levels.
Source: VGC_News - 🏆 125. / 51 Read more »
Why no team wants to be top of the timesheet in Formula 1 pre-season testingRecent history tells us the teams who show their pace in Formula 1 pre-season testing are the ones most likely to disappoint.
Source: Planet_F1 - 🏆 126. / 51 Read more »
New Giuliani Doc Links Recent Behavior to Pre-9/11 HistoryMore than two decades ago, he was hailed as “Mayor of the World.” Now Rudy Guiliani’s image is entwined with Donald Trump’s presidency, particularly his efforts to overturn the results of the 2020 election Too much booze🤣 You all hate him because you've been programmed to hate Trump and anyone in his circle. He ran afoul of the narrative and stuck with his convictions.
Source: TIME - 🏆 93. / 53 Read more »
Selena Gomez’s 7-Step Pre-Flight Skincare Routine In All Its GlorySelena Gomez took to TikTok to showcase her seven-step pre-flight skincare routine and it's full of must-have products. 👑❤️
Source: GraziaUK - 🏆 15. / 78 Read more »