Life reporter at HuffPost UK.
Life reporter at HuffPost UK
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Epigenetic and transcriptomic reprogramming in monocytes of severe COVID-19 patients reflects alterations in myeloid differentiation and the influence of inflammatory cytokines - Genome MedicineBackground COVID-19 manifests with a wide spectrum of clinical phenotypes, ranging from asymptomatic and mild to severe and critical. Severe and critical COVID-19 patients are characterized by marked changes in the myeloid compartment, especially monocytes. However, little is known about the epigenetic alterations that occur in these cells during hyperinflammatory responses in severe COVID-19 patients. Methods In this study, we obtained the DNA methylome and transcriptome of peripheral blood monocytes from severe COVID-19 patients. DNA samples extracted from CD14 + CD15- monocytes of 48 severe COVID-19 patients and 11 healthy controls were hybridized on MethylationEPIC BeadChip arrays. In parallel, single-cell transcriptomics of 10 severe COVID-19 patients were generated. CellPhoneDB was used to infer changes in the crosstalk between monocytes and other immune cell types. Results We observed DNA methylation changes in CpG sites associated with interferon-related genes and genes associated with antigen presentation, concordant with gene expression changes. These changes significantly overlapped with those occurring in bacterial sepsis, although specific DNA methylation alterations in genes specific to viral infection were also identified. We also found these alterations to comprise some of the DNA methylation changes occurring during myeloid differentiation and under the influence of inflammatory cytokines. A progression of DNA methylation alterations in relation to the Sequential Organ Failure Assessment (SOFA) score was found to be related to interferon-related genes and T-helper 1 cell cytokine production. CellPhoneDB analysis of the single-cell transcriptomes of other immune cell types suggested the existence of altered crosstalk between monocytes and other cell types like NK cells and regulatory T cells. Conclusion Our findings show the occurrence of an epigenetic and transcriptional reprogramming of peripheral blood monocytes, which could be associated with the
Source: BioMedCentral - 🏆 22. / 71 Read more »
Oil Prices Climb As China Continues To Ease Covid Restrictions | OilPrice.comOil prices were up on Monday morning as China continued to relax its Covid restrictions, although reports of two Covid-related deaths could change that
Source: OilandEnergy - 🏆 34. / 68 Read more »
Shropshire Council cabinet member steps down to recover from impact of CovidA senior county councillor has stepped down from his cabinet post due to the long-term impacts of Covid. Not good, hope he improves. Ironic that he is responsible for public health...with no precautions or mitigations at all I imagine public service is very dangerous now.
Source: ShropshireStar - 🏆 98. / 51 Read more »
Lancashire Covid hotspots in 10 districts as we head into ChristmasSeveral areas are still a lot higher than the rest of Lancashire
Source: LiveLancs - 🏆 10. / 87 Read more »
Exploring effects of COVID-19 pandemic on neurodevelopment and mental health in adolescentsExploring effects of COVID-19 pandemic on neurodevelopment and mental health in adolescents Stanford COVID19 SARSCoV2 Neurodevelopment MentalHealth
Source: NewsMedical - 🏆 19. / 71 Read more »
Impact of COVID-19 booster vaccination and breakthrough infectionResearchers assessed the protection elicited after a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) booster vaccination or a breakthrough infection against SARS-CoV-2 Omicron variant infection.
Source: NewsMedical - 🏆 19. / 71 Read more »